Medical aesthetics - Exposure exposure® dermatological aloe vera gel

PRODUCT DETAILED INFORMATION

exposure® dermatological arnica gel

DESCRIPTION
Exposure® Dermatological Arnica Gel is an original formulation with anti-inflammatory, soothing and regenerative skin properties (for external use only).

MAIN INGREDIENTS
Aqua, alcohol, glycerin, peg/ppg-14/4 dimethicone, arnica montana extract, acrylates/c10-30 alkylacrylate crosspolymer, sodium hydroxyde, disodium edta, methylisothiazolinone.

INDICATIONS
Prevention of haematoma formation (bruises). Treatment of the following:

post-surgical haematoma
small bruises caused by injections of botulinum toxin, dermal fillers, etc.
muscular sprains
ostheoarthritis symptoms

and in general to soothe, refresh and stimulate skin healing.

PROPERTIES
Exposure® Dermatological Arnica Gel uses an innovative original formula. The combination of a high concentration of arnica montana and dimethicone provides:

analgesic properties (soothing and pain relief from muscle sprain)
anti-inflammatory properties
reabsorption of existing haematoma (bruises)
bruising prevention
skin repair

DIRECTIONS
Suitable for all skin types. Apply gently to affected areas as often as required, or as directed by your Doctor.
Exposure® Dermatological Arnica Gel is suitable for use in face and body.

WARNING
Topical use only. Do not apply to eyes, mucose membranes and/or open wounds.
Some patients experience breakouts any time they change their skin care regimen. Skin reactions to any new topical product, though rare, are likely to occur within the first few days of use. If any reaction occurs, wash the product off and discontinue use.

CONTRAINDICATIONS
Prior history of sensitivity or allergic reaction to this product or any of its ingredients.

ADVERSE REACTIONS
No systemic adverse reactions have been reported. In rare cases, hypersensitivity (localized contact dermatitis) may occur: gel application should be discontinued and the physician notified immediately.

KEEP OUT OF THE REACH AND SIGHT OF CHILDREN

Not tested on animals
Manufactured in the EC for Medical Aesthetics Ltd., London, UK.

BIBLIOGRAPHY
1. Effect of Arnica montana on bruising in face-lifts: results of a randomized, double-blind, placebo-controlled clinical trial. Seeley BM, Denton AB, Ahn MS, Maas CS. Arch Facial Plast Surg. 2006 Jan-Feb;8(1):54-9.
2. Efficacy of Arnica in varicose vein surgery: results of a randomized, double-blind, placebo-controlled pilot study. Wolf M, Tamaschke C, Mayer W, Heger M. Forsch Komplementarmed Klass Naturheilkd. 2003 Oct;10(5):242-7.
3. Arnica montana gel in osteoarthritis of the knee: an open, multicenter clinical trial. Knuesel O, Weber M, Suter A. Adv Ther. 2002 Sep-Oct;19(5):209-18.
4. Helenalin, an anti-inflammatory sesquiterpene lactone from Arnica, selectively inhibits transcription factor NF-kappaB. Lyss G, Schmidt TJ, Merfort I, Pahl HL. Biol Chem. 1997 Sep;378(9):951-61.
5. Skin penetration studies of Arnica preparations and of their sesquiterpene lactones. Wagner S, Suter A, Merfort I. Planta Med. 2004 Oct;70(10):897-903.
6. New sesquiterpene lactones from Arnica tincture prepared from fresh flowerheads of Arnica montana. Kos O, Lindenmeyer MT, Tubaro A, Sosa S, Merfort I.
Planta Med. 2005 Nov;71(11):1044-52.
7. Granny's remedy explained at the molecular level: helenalin inhibits NF-kappaB. Schaffner W. Biol Chem. 1997 Sep;378(9):935.
8. Studies on the anti-inflammatory activity of phytopharmaceuticals prepared from Arnica flowers. Klaas CA, Wagner G, Laufer S, Sosa S, Della Loggia R, Bomme U, Pahl HL, Merfort I. Planta Med. 2002 May;68(5):385-91.
9. Sesquiterpene lactones specifically inhibit activation of NF-kappa B by preventing the degradation of I kappa B-alpha and I kappa B-beta. Hehner SP, Heinrich M, Bork PM, Vogt M, Ratter F, Lehmann V, Schulze-Osthoff K, Droge W, Schmitz ML. J Biol Chem. 1998 Jan 16;273(3):1288-97.
10. Sesquiterpene lactone parthenolide blocks lipopolysaccharide-induced osteolysis through the suppression of NF-kappaB activity. Yip KH, Zheng MH, Feng HT, Steer JH, Joyce DA, Xu J. J Bone Miner Res. 2004 Nov;19(11):1905-16. Epub 2004 Sep 27.
11. Sesquiterpene lactones are potent inhibitors of interleukin 8 gene expression in cultured human respiratory epithelium. Mazor RL, Menendez IY, Ryan MA, Fiedler MA, Wong HR. Cytokine. 2000 Mar;12(3):239-45.
12. Quantitative structure-activity relationship of sesquiterpene lactones as inhibitors of the transcription factor NF-kappaB. Siedle B, Garcia-Pineres AJ, Murillo R, Schulte-Monting J, Castro V, Rungeler P, Klaas CA, Da Costa FB, Kisiel W, Merfort I. J Med Chem. 2004 Nov.
13. Lignans from Arnica species. Schmidt TJ, Stausberg S, Raison JV, Berner M, Willuhn G. Nat Prod Res. 2006 May 10;20(5):443-53.

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